Neutrophils, a set of immune cells, from people with aquaporin-4 (AQP4) antibody-positive neuromyelitis optica spectrum disorder (NMOSD) are resistant to certain forms of cell death, a study found. NMOSD patients also had increased blood levels of molecules that might help neutrophils resist cell death pathways. Similar findings weren’t observed…
symptoms
The incidence of pain in adults with neuromyelitis optic spectrum disorder (NMOSD) is high and was reported as the first sign of an inflammatory attack in half of patients, according to an examination of medical records. Neuropathic (nerve-related) pain, marked by uncomfortable burning or tingling, was the most common…
Optic nerve fiber damage is usually more severe in people with neuromyelitis optica spectrum disorder (NMOSD) than with idiopathic optic neuritis, based on a clinical measure called visual evoked potential, a study shows. Results also suggest the recovery window after an acute NMOSD attack is shorter, highlighting the importance…
Measuring the retinal nerve layers by a non-invasive tool called optical coherence tomography may help to diagnose neuromyelitis optica spectrum disorder (NMOSD), especially in those who test negative for disease-related antibodies, according to a new study. Researchers found that nerve layers in the retina of people with NMOSD…
Age, sex, and spinal lesions may be risk factors for developing pain due to nerve damage — called neuropathic pain — in people with neuromyelitis optica spectrum disorder (NMOSD), according to a new study. Specifically, an older age at disease onset, female sex, and a greater number of lesions…
Impairments in the visual field — the total area in which objects can be seen in a person’s peripheral vision — were found in adults with optic neuritis (ON) related to neuromyelitis optica spectrum disorder (NMOSD), according to a new study. NMOSD patients with optic neuritis had more visual…
The CoronaVac vaccine, which contains inactivated SARS-CoV-2, the virus that causes COVID-19, led to a severe case of late-onset neuromyelitis optica spectrum disorder (NMOSD) in a 70-year-old woman. The unique case was described in an article, “Fulminant neuromyelitis optica spectrum disorder (NMOSD) following COVID-19 vaccination: A…
One of the most important jobs new parents have is to protect their children from pain. I am a mother of three, and every time one of my kids gets hurt, I want to take on the pain myself. When my youngest daughter, Bella, was hospitalized with neuromyelitis…
A man’s first manifestation of neuromyelitis optica spectrum disorder (NMOSD) was aseptic meningitis, an inflammation of the meninges (the membranes that enclose the brain and spinal cord) without evidence of a bacterial infection, which is unusual and made a quick diagnosis difficult, says a report from Japan. The man…
Key players in B-cell signaling pathways and related inflammatory molecules were elevated in the blood of people with neuromyelitis optica spectrum disorder (NMOSD) compared with healthy people, a study found. The findings suggest that targeting this signaling pathway could show therapeutic promise in NMOSD, the researchers noted. The study,…