Women with elevated blood levels of the sex hormone progesterone have an increased risk of developing neuromyelitis optica spectrum disorder (NMOSD), according to a study that analyzed genetic variants associated with sex hormone levels. In a reverse analysis, having NMOSD appeared to lower testosterone and increase the sex hormone-binding…
risk factors
People with neuromyelitis optica spectrum disorder (NMOSD) have significantly lower vitamin D levels in their blood than do healthy individuals, according to a meta-analysis of data from studies covering more than 900 people in Asia. While the findings don’t prove that vitamin D deficiency causes NMOSD, they call attention…
The risk of developing type 2 diabetes is more than 50% higher among people with neuromyelitis optica spectrum disorder (NMOSD) compared with matched people without the neurological condition, a study found. Results suggest that the risk of diabetes is particularly high in NMOSD patients who have receive treatment with…
People with neuromyelitis optica spectrum disorder (NMOSD) who have experienced only one relapse tend to underestimate their risk of future relapses, but patients who’ve had multiple relapses tend to overestimate this risk, a small study has found. The findings underscore the importance of clear communication with healthcare providers so…
People with neuromyelitis optica spectrum disorder (NMOSD) are at an increased risk of being diagnosed with another autoimmune disease — specifically lupus or Sjögren’s syndrome — according to a large-scale analysis of inpatient hospitalization data in the U.S. In fact, NMOSD patients had a 12 times higher…
About 1 in 10 people who are hospitalized for neuromyelitis optica spectrum disorder (NMOSD) are readmitted to the hospital within 30 days, or about one month after discharge, a U.S. study found. Older patients — specifically those in the age range of 65 to 74 — and individuals who…
People with a genetic makeup that causes them to be more susceptible to COVID-19 are nearly five times as likely to develop neuromyelitis optica spectrum disorder (NMOSD) associated with antibodies against aquaporin-4 (AQP4), a study finds. Evidence for a cause and effect, or causal, link between COVID-19 and NMOSD…
Genetic variations linked with cold sores and shingles infections have been associated with the development of AQP4 antibody-positive neuromyelitis optica spectrum disorder (NMOSD), according to genetic analysis. The findings suggest that the herpes simplex virus, which is the cause of cold sores, and the varicella-zoster virus, which leads to…
A history of smoking is associated with poorer recovery from disease relapses in people with neuromyelitis optica spectrum disorder (NMOSD), a study reports. Findings indicate that patients who smoke or are past smokers are more likely to have neurological lesions that persist months after the relapse, and that these…
The presence of certain self-reactive antibodies called antinuclear antibodies (ANAs) in the blood is associated with worse disability and more severe relapses in people with neuromyelitis optica spectrum disorder (NMOSD), according to a study from China. “Our results suggest that ANA seems to be more associated with severe disease…
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