The composition of bacteria in the gut is altered in neuromyelitis optica spectrum disorder (NMOSD) patients experiencing disease relapses compared with healthy people in the same household, a study reports. Following treatment, however, the gut bacterial profiles of NMOSD patients in remission resembled those of healthy people. “The…
Disease progression
A seaweed-derived preparation named GV-971 (sodium oligomannate) that has anti-inflammatory effects through the gut-brain axis, delayed the onset and progression of neuromyelitis optica spectrum disorder (NMOSD) in mouse models of the disease, a study shows. The preparation developed by Green Valley Pharmaceuticals is approved in China as an…
About half of neuromyelitis optica spectrum disorder (NMOSD) patients who test positive for self-reactive antibodies, or autoantibodies, against the AQP4 protein — a hallmark of the autoimmune disease — have at least one other type of autoantibody, according to a new study from South Korea. Many of these other…
In the five years before their first disease attack, people with neuromyelitis optica spectrum disorder (NMOSD) required significantly more doctor’s office visits and hospitalizations than their peers in the general population, a new study from Canada found. The researchers believe these findings point to the presence of an NMOSD…
Experiencing attacks marked by transverse myelitis, or spinal cord inflammation, significantly increases the chance of worse disability in people with neuromyelitis optica spectrum disorder (NMOSD) patients and the related condition myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Those are the findings of a study analyzing data from a Portuguese national…
Age at disease onset and sex ratio — the ratio of males to females — among people with neuromyelitis optica spectrum disorder (NMOSD) are influenced by the proportion of cases with antibodies against aquaporin-4 (AQP4). That’s according to a review study from an international team of researchers that sheds…
The circulating levels in the blood of six inflammatory proteins may help predict the risk of relapse and severe attacks in people with neuromyelitis optica spectrum disorder (NMOSD), a study from China reports. Four of these inflammation-related proteins — FGF-23, DNER, GDNF, and SLAMF1 — were used to build…
People having area postrema syndrome (APS), that is, uncontrollable nausea, vomiting, or hiccups, as the first symptom of neuromyelitis optica spectrum disorder (NMOSD) are more likely to relapse sooner and more frequently than those having another first symptom. These are the main findings of a single-center study that retrospectively…
The risk of developing type 2 diabetes is more than 50% higher among people with neuromyelitis optica spectrum disorder (NMOSD) compared with matched people without the neurological condition, a study found. Results suggest that the risk of diabetes is particularly high in NMOSD patients who have receive treatment with…
Under normal circumstances, immune B-cells train T-cells, another type of immune cell, on which targets not to attack, preventing the development of neuromyelitis optica spectrum disorder (NMOSD), according to a study in mice. This training occurs in the thymus gland, a small organ behind the breastbone that works as…
Recent Posts
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