NMOSD

Experiencing attacks marked by transverse myelitis, or spinal cord inflammation, significantly increases the chance of worse disability in people with neuromyelitis optica spectrum disorder (NMOSD) patients and the related condition myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Those are the findings of a study analyzing data from a Portuguese national…

Maintenance treatment with rituximab significantly reduced the number of relapses per year in people with neuromyelitis optica spectrum disorder (NMOSD), and it remained effective after patients experienced relapses, according to a study from China. Relapses more frequently occurred within the first year after rituximab initiation, and their frequency decreased…

People having area postrema syndrome (APS), that is, uncontrollable nausea, vomiting, or hiccups, as the first symptom of neuromyelitis optica spectrum disorder (NMOSD) are more likely to relapse sooner and more frequently than those having another first symptom. These are the main findings of a single-center study that retrospectively…

People with neuromyelitis optica spectrum disorder (NMOSD) experience faster disability progression with fewer attacks than those with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), a related condition, according to a long-term analysis of German registry data. Notably, in all patients, experiencing inflammation in the optic nerve, which transmits signals between…

Certain neurological symptoms of neuromyelitis optica spectrum disorder (NMOSD) occur at higher rates in patients who also have systemic lupus erythematosus (SLE), according to a recent review study. Features of NMOSD, including longitudinally extensive transverse myelitis — a type of spinal cord inflammation — and involvement of certain…

Nearly two in 10 neuromyelitis optica spectrum disorder (NMOSD) patients develop new asymptomatic brain and spinal cord lesions during the period of disease remission, but these do not appear to increase risk of relapse, according to a study in Argentina. Asymptomatic, or silent, lesions are those that can be…

Having optic neuritis — inflammation of the nerves that relay information between the eyes and the brain — as a first symptom of neuromyelitis optica spectrum disorder (NMOSD) is one of the factors that predict visual disability in up to five years, according to a study in China. Other…

Brain and spinal cord lesions resolve less often in children with neuromyelitis optica spectrum disorder (NMOSD) than with myelin oligodendrocyte glycoprotein antibody disease (MOGAD), a related disorder, according to a small study. No significant differences in resolving lesions were seen between children with NMOSD and those with multiple…

SPHERES, a real-world registry for neuromyelitis optica spectrum disorder (NMOSD), is now collecting biological samples from consenting participants. Launched by CorEvitas and the Guthy-Jackson Charitable Foundation (GJCF) in 2021, the registry had been collecting long-term clinical data, but not biological samples. “The launch of this biospecimen…

High-efficacy treatments for neuromyelitis optica spectrum disorder (NMOSD) are associated with significant reductions in hospitalizations, relapses, and MRI lesions relative to traditional therapies, according to a recent study. The findings, which were published in the Journal of Neurology, were discussed in an oral presentation at the American…