Early immunosuppressive therapy better in AQP4-positive NMOSD

Early use of immunosuppressive therapy — when compared with a later treatment start — was associated with fewer relapses and reduced disability among neuromyelitis optica spectrum disorder (NMOSD) patients with self-reactive antibodies against the AQP4 protein, a study from China showed. The data demonstrated a time-dependent treatment efficacy, with…

Immunosuppressive therapy found effective in elderly NMOSD patients

Immunosuppressive therapy significantly reduces relapses in elderly people with late-onset neuromyelitis optica spectrum disorder (NMOSD), with more than half of patients becoming relapse-free, a retrospective study in South Korea has found. Treatment also eased or stabilized disability for most patients, without a marked risk of severe infections, and was…

Risk factors ID’d for NMOSD relapse with immunosuppressive treatment

People who are younger at the onset of neuromyelitis optica spectrum disorder (NMOSD) and those with multiple organ involvement at the first attack by the disease have a higher risk of relapse during treatment with traditional immunosuppressants, a study showed. A reduction in the levels of antibodies against…

Immunosuppressants May Help Lower Risk of Relapse in Pregnancy

Women with neuromyelitis optica spectrum disorder (NMOSD) who received immunosuppressive treatment during pregnancy or were at least 32 years old when they conceived may be at a lower risk of pregnancy-associated relapses, a systematic review study has found. Data also showed the risk of relapse is highest in the…