AQP4-negative

No Astrocyte Damage Found in Patients Lacking Anti-AQP4 Antibodies

People with neuromyelitis optica spectrum disorder (NMOSD), but lacking anti-AQP4 and anti-MOG antibodies, show no signs of damage to astrocytes — nervous system cells attacked in NMOSD — when compared to those with anti-AQP4 antibodies. Those findings from a recent study suggest that the mechanisms underlying NMOSD symptoms in…

Uplizna May Be Effective for Patients Without Anti-AQP4 Antibodies

Long-term treatment with Uplizna (inebilizumab-cdon) safely and effectively reduced the frequency of attacks in the 12 neuromyelitis optica spectrum disorder (NMOSD) patients who were negative for antibodies against aquaporin-4 (AQP4) in the N-MOmentum Phase 2/3 trial. Future, appropriately-controlled studies are needed to confirm Uplizna’s benefits in this subgroup…