People with neuromyelitis optica spectrum disorder (NMOSD) have significantly lower vitamin D levels in their blood than do healthy individuals, according to a meta-analysis of data from studies covering more than 900 people in Asia. While the findings don’t prove that vitamin D deficiency causes NMOSD, they call attention…
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Immune T-cells of the CAR T-cell therapy CT103A are able to rapidly eliminate disease-driving immune cells and reduce immune cells’ overall inflammatory activity in people with neuromyelitis optica spectrum disorder (NMOSD), a study shows. “This study is the first in-depth single-cell … analysis of multiple types of body fluids…
The risk of developing type 2 diabetes is more than 50% higher among people with neuromyelitis optica spectrum disorder (NMOSD) compared with matched people without the neurological condition, a study found. Results suggest that the risk of diabetes is particularly high in NMOSD patients who have receive treatment with…
Most neuromyelitis optica spectrum disorder (NMOSD) patients who start taking Enspryng (satralizumab) remain free of relapses for at least a year, with some being able to stop treatment with oral glucocorticoids, according to a study of real-world data. The findings are consistent with those of SAkuraStar (NCT02073279)…
None of the neuromyelitis optica spectrum disorder (NMOSD) patients in the Phase 3 CHAMPION-NMOSD clinical trial have had a disease relapse while on Ultomiris (ravulizumab-cwvz) treatment for a median of more than 2.5 years. These findings were shared by Sean Pittock, MD, the trial’s principal investigator, at the…
International research has uncovered a series of immune-related events that might contribute to the abnormal immune responses against the aquaporin-4 protein (AQP4), which drives neuroinflammation in cases of neuromyelitis optica spectrum disorder (NMOSD). Among the implicated immune cell types are natural killer T-cells (NKT), which seem to be first…
Three months of ginseng tablets taken twice a day lessened fatigue in people with neuromyelitis optica spectrum disorder (NMOSD), a placebo-controlled Phase 3 clinical trial found. Ginseng is a plant that has been used in traditional Chinese medicine for thousands of years. “This study revealed positive effects of ginseng…
A severe attack or a higher annual relapse rate before starting azathioprine or mycophenolate mofetil (MMF) was associated with a poor response in people with neuromyelitis optica spectrum disorder (NMOSD), a small study shows. An unsatisfactory response to either treatment, defined as a severe relapse or two or more…
The U.S. Food and Drug Administration (FDA) has approved Ultomiris (ravulizumab-cwvz) to treat adults with neuromyelitis optica spectrum disorder (NMOSD) who are positive for antibodies against the aquaporin-4 (AQP4) protein. About 75% of people with NMOSD produce antibodies that bind to AQP4, according to the therapy’s developer, Alexion…
A significant proportion of neuromyelitis optica spectrum disorder (NMOSD) patients in the U.S. lost employment, work hours, and wages after their diagnosis, as motor and visual disability and symptoms like pain and fatigue hurt their productivity, a study has found. Older patients, those using mobility aids, and those…
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