An international team of researchers identified a self-reactive antibody that may explain cases of neuromyelitis optica spectrum disorder (NMOSD)-like disease that test negative for known NMOSD-causing antibodies. Self-reactive antibodies against the protein modulator VRAC current 1 (MLC1) were identified in multiple people with NMOSD-like disease who lacked known disease-causing…
Discussion
Living with neuromyelitis optica spectrum disorder (NMOSD) means I’ve become something of a detective. I’m not the glamorous kind with a trench coat and a magnifying glass like Sherlock Holmes, but more like a tired, slightly bewildered Inspector Gadget who wakes up every morning trying to figure out what’s…
Discussion
Treatment with Uplizna (inebilizumab-cdon) was associated with fewer attacks and reduced disability in Chinese adults with neuromyelitis optica spectrum disorder (NMOSD) who have anti-aquaporin-4 (AQP4) antibodies, a real-world study found. The estimated one-year attack-free rate was 95.5%. According to the researchers, the findings “provided evidence on the real-world…
NMOSD is a progressive autoimmune disease where the immune system mistakenly attacks nerve cells, affecting the nervous system. Learn more about the disease here.
Scientists do not know the exact underlying cause of NMOSD. Self-reactive antibodies that target AQP4 are known to play a major role. Learn more about what causes the disease here.
When the disease affects the optic nerve (optic neuritis), it can result in pain inside the eye and possibly blurry vision or vision loss. Learn more about the symptoms of the disease here.
Get regular updates to your inbox.
